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A Common Cut in Cocaine May Prove Deadly

Jan 20, 2010

Levamisole, a drug used by veterinarians to get rid of worms, has become increasingly popular as a "cut," or diluting agent, in cocaine and possibly some heroin. In humans, levamisole can cause agranulocytosis, a life-threatening immune-system disorder that kills 7% to 10% of patients and is rare except in chemotherapy patients and those taking certain antipsychotic medications. Levamisole is now found in 70% of all cocaine seized in the United States, up from 30% in 2008. One possible explanation for the surge of levamisole use is that the drug may enhance both highs and cravings. "It may increase dopamine and by so doing may enhance cocaine effects," said Dr. Nora Volkow, director of the National Institute on Drug Abuse. There have been several dozen cases of cocaine-related agranulocytosis reported in North America—and one known death.

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TIME